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. 2023 May 11;14:2657. doi: 10.1038/s41467-023-38244-8

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 8 — The expression level of Nluc was evaluated four hours after intravenous injection of mRNA lipid nanoparticles (LNPs) into mice. The cap analog used for mRNA preparation is indicated in the Figure. AnP means the mRNA was further treated with Antarctic phosphatase. (a) In vivo images of mice. (b, c) Quantifying Nluc expression levels using homogenates of the liver (b) and spleen (c). Data are mean ± s. e. m. for biological replicates (n = 8). The statistically significant differences in one-way ANOVA followed by Tukey’s test were marked as follows: ns, p > 0.05 (not significant); *, p < 0.05; **, p < 0.01; ***, p < 0.001, ****, p < 0.0001. (a‒c) Each experiment was repeated independently at least twice to obtain similar results. Source Data are provided with this paper.