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. 2023 May 11;14:2350. doi: 10.1038/s41467-023-37824-y

Fig. 1. A positive p140Cap status directly correlates with the presence of TILs and inversely with inflammatory hallmarks in human BC.

Fig. 1

a Representative images of p140Cap and H&E staining, showing TILs, in HER2 negative and HER2 positive tumor breast tissues from 390 female patients. Black arrows point to TILs; red arrows indicate to cancer. Mag, magnifications. Bars, 200, 100 µm. b Quantitative analysis of the presence of TILs (positive or negative) according to p140Cap status (p140CapLOW, IHC score <1; p140CapHIGH, IHC score ≥1), evaluated on H&E stained TMA cores in All patients, as well as in HER2-negative and HER2-positive patients. OR odds ratio, CI confidence interval; p-value by Pearson’s Chi-Squared Test. c GSEA32,33 plot showing the behavior of the “Hallmark_Inflammatory_Response” Gene Set from MSigDB~5.0 in the cohort of 1095 BC female patients from TCGA 34, stratified according to SRCIN1 transcript levels. The plot shows the distribution of genes in the set that are correlated or not with SRCIN1 expression; two-tailed unpaired t test.