Table 5.

Associations of clinical factors with PV status among women unaffected with cancer of any type

Clinical Factor	Gene	Odds Ratio	Lower 95% CI	Upper 95% CI	P-Value
Female relative w/BC (Any vs. None)	ATM	1.09	0.96	1.24	1.67E − 01
	CHEK2	1.24	1.11	1.38	8.00E − 05
	PALB2	2.12	1.74	2.58	7.16E − 14
	BRCA1	2.05	1.84	2.28	1.55E − 39
	BRCA2	1.81	1.65	2.00	1.87E − 33
	ATM, CHEK2, PALB2	1.29	1.20	1.40	1.52E − 11
	BRCA1/2	1.91	1.78	2.05	1.57E − 69
Female relative w/BC (≤ 45 vs. > 45)	ATM	0.95	0.86	1.06	3.88E − 01
	CHEK2	1.07	0.98	1.17	1.12E − 01
	PALB2	0.98	0.86	1.11	7.48E − 01
	BRCA1	2.34	2.13	2.56	6.64E − 72
	BRCA2	1.25	1.16	1.35	6.81E − 09
	ATM, CHEK2, PALB2	1.01	0.96	1.08	6.25E − 01
	BRCA1/2	1.64	1.54	1.73	1.25E − 60

BC, breast cancer; CI, confidence interval

All models were adjusted for family history of ovarian, pancreatic, prostate, male breast cancer, and ancestry