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. 2023 Apr 8;199(2):281–291. doi: 10.1007/s10549-023-06914-2

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© The Author(s) 2023

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Distribution of ROR1 and ROR2 expression by HR/HER2 subtype. a, b Violin plots of log2-scaled normalized a ROR1 and b ROR2 expression by HR and HER2 status. Asterisks reflects pairwise Wilcoxon-rank sum test p values (*** p < 0.0001, **0.0001 < p < 0.001, *0.001 < p < 0.05). Color denotes receptor subtype (pink: HR + HER2-, green: HR + HER2 +, aqua: HR- HER2-, purple: HR-HER2) c Scatter plot of ROR2 vs. ROR1 expression level. Color reflects receptor subtype (pink: HR + HER2-, green: HR + HER2 +, aqua: HR- HER2-, purple: HR- HER2+). Dotted lines indicate median ROR1 and ROR2 expression values, which were used to define four patient subsets by dichotomized ROR1 and ROR2 expression (ROR1 above median: ROR1-High; ROR2 above median: ROR2-High). d Distribution of dichotomized ROR1/ROR2 expression subsets by HR and HER2 status. Color reflects ROR1/ ROR2 expression groups (red: ROR1-High/ROR2-High (HH); orange: ROR1-High/ROR2-Low (HL); light blue: ROR1-Low/ROR2-High (LH); blue: ROR1-Low/ROR2-Low (LL)