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. 2023 May 11;381(4):16. doi: 10.1007/s41061-023-00426-9

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© The Author(s) 2023

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a Diagram of the cLC-MS system. Reprinted from Journal of Neuroscience Methods, 159/1, Holly M. Shackman, Minshan Shou, Nicholas A. Cellar, Christopher J. Watson, Robert T. Kennedy, Microdialysis coupled on-line to capillary liquid chromatography with tandem mass spectrometry for monitoring acetylcholine in vivo, 86–92, Copyright (2007), with permission from Elsevier. b Comparison of mass chromatograms for ACh in standard solution prepared in CSF and basal levels from the striatum of a ketamine anesthetized rat, where: A ACh standard at concentration 330 pM and B corresponding to selected reaction monitoring (SRM) MS/MS spectra, c basal ACh, and D corresponding to SRM MS/MS spectra. Reprinted from Journal of Neuroscience Methods, 159/1, Holly M. Shackman, Minshan Shou, Nicholas A. Cellar, Christopher J. Watson, Robert T. Kennedy, Microdialysis coupled on-line to capillary liquid chromatography with tandem mass spectrometry for monitoring acetylcholine in vivo, 86–92, Copyright (2007), with permission from Elsevier