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. 2023 Mar 25;145(6):733–747. doi: 10.1007/s00401-023-02564-2

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© The Author(s) 2023

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — TREM2 correlations with microglial density components. a Caudate but not cortical TREM2 mRNA is significantly correlated with several components of microglial density including the activated component cis-regionally. Midfrontal cortex (mfCx); ventral medial caudate (vmCaudate). A Pearson’s correlation coefficient (r) is displayed for each comparison. An asterisk denotes significance set to an a priori threshold of p < 0.05. b Caudate TREM2 mRNA levels by the proportion of activated microglial density (PAM) stages 2–3. Unadjusted scatter plots and statistical results from linear regression models adjusting for age at death, sex, education, and post-mortem interval