Table 3.

Selected small molecules with excellent kinase inhibition activity

Compounds	Chemical Structures	Targets	IC50	References
1		VEGFR-2	0.19 nM	471
2		VEGFR-2	2.6 nM	472
3		VEGFR-2	3.2 nM	473
4		VEGFR-2	3.2 nM	474
5		VEGFR-2	27 nM	475
6		VEGFR-2	66 nM	476
7		VEGFR-2	0.12 μM	477
8		VEGFR-2	0.12 μM	478
9		VEGFR-2	0.23 μM	479
10		VEGFR-2	0.29 μM	480
11		VEGFR-2	0.31 μM	481
12		VEGFR-2 PDGFR-β	24.7 nM 16.1 nM	481
13		VEGFR-2 FGFR-1 PDGFR-β	7 nM 69 nM 31 nM	482
14		VEGFR-2 FGFR-1 PDGFR-β	0.18 μM 0.23 μM 0.1 μM	481
15		VEGFR-2 c-Met PDGFR-β	435 nM 654 nM 371 nM	481,483
16		VEGFR-2 Tie-2 EphB4	1.05 nM 2.47 nM 0.27 nM	484,485
17		VEGFR-2 Tie-2 EphB4	1.85 nM 0.73 nM 2.99 nM	486
18		VEGFR-2 Tie-2 EphB4	2.35 nM 5.63 nM 3.87 nM	487
19		VEGFR-2 HDAC4	5 μM 0.36 μM	488
20		FGFR-4	5.4 nM	489
21		FGFR-1 FGFR-2 VEGFR-2	1.0 nM 4.5 nM 2.9 nM	490
22		FGFR-1 FGFR-2 FGFR-3	0.6 μM 1.3 μM 4.1 μM	491
23		HIF-1α	0.6 μM	492
24		HIF-1α	0.32 μM	493
25		HIF-1α	0.6 μM	494