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. 2023 May 11;13:7648. doi: 10.1038/s41598-023-34571-4

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Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Determination of hypoxia progression in melanoma spheroids. The hypoxic region is observed in the center of spheroids in (A) WM266-4 and (B) WM115 cell lines with significant differences in the larger and older spheroids. Plot of hypoxia distribution in WM266-4 (C) and WM115 (D) spheroids at two different culture time points as assessed with the Image-IT™ Green Hypoxia probe.