FIGURE 11.

Effects of WZ4003 on non-adrenergic contractions of human prostate tissues. Contractions of human prostate tissues were induced by U46619 (A,B) or endothelin-1 (C,D) in an organ bath, 30 min after addition of WZ4003 in concentrations of 500 nM (A,C) or 10 µM (B,D) or of an equivalent amount of DMSO (controls), which was used as solvent for WZ4003. Shown are data from n = 5 independent experiments in each subpanel, where tissues from n = 5 patients were used for both groups of a subpanel, resulting in paired samples. Shown are means ± SD from all experiments in concentration response curves with p values from two-way ANOVA for whole groups, and all single E_max and EC₅₀ values from all experiments (calculated by curve fitting) in scatter plots.