Table 1.
Outlines the changes made to the nomenclature/diagnostic criteria for nodal PTCL’s.
| 2022 ICC Classification | 2022 WHO classification | 2017 updated WHO classification |
Comments |
|---|---|---|---|
| Peripheral T-cell lymphoma, not otherwise specified | Peripheral T-cell lymphoma, not otherwise specified | Peripheral T-cell lymphoma, not otherwise specified | Remains a diagnosis of exclusion; Two biological variants - PTCL-TBX21 and PTCL-GATA3 are identified. Cytotoxic EBV-negative cases may represent a distinct subgroup |
| TFH lymphoma, angioimmunoblastic subtype | Nodal TFH cell lymphoma, angioimmunoblastic-type | Angioimmunoblastic T cell lymphoma | Diagnostic criteria is unchanged. Grouped under nodal T follicular helper cell lymphoma (TFH). New terminology introduced to group lymphomas with similar phenotype and gene expression profiling signatures. |
| TFH lymphoma, follicular type | Nodal TFH cell lymphoma, follicular-type | Follicular T cell lymphoma | New nomenclature. Diagnostic criteria is unchanged. |
| TFH lymphoma, NOS | Nodal TFH cell lymphoma, NOS | Nodal peripheral T-cell lymphoma with TFH phenotype | New nomenclature. Diagnostic criteria is unchanged. |
| Anaplastic large cell lymphoma, ALK positive | ALK positive, Anaplastic large cell lymphoma | Anaplastic large cell lymphoma, ALK-positive | No change in diagnostic criteria |
| Anaplastic large cell lymphoma, ALK negative | ALK negative, Anaplastic large cell lymphoma | Anaplastic large cell lymphoma, ALK-positive | No change in the diagnostic criteria. Recognized as a heterogenous entity. TP63 rearrangements, |
| Breast implant associated ALCL | Breast implant associated ALCL | Breast implant associated ALCL | Overexpression of PD-L1 in over half the cases Constitutive JAK-STAT activation by somatic mutations of STAT3, STAT5B, JAK1 and JAK2 and loss-of function mutations of SOCS1 and SOCS3 |
| Primary nodal EBV+ NK/T cell lymphoma | EBV+ve nodal NK and T cell lymphoma | New entity | New distinct entity from PTCL -NOS. Now grouped under EBV+ve positive NK/T cell lymphomas |
The table compares the nomenclature differences between the recent classifcations for nodal T cell lymphomas to the 2017 revised WHO classification. 2022 (ICC) International consensus classification of mature lymphoid neoplasms;. 2022 (WHO) World health organization classification of T cell lymphomas. TFH, T follicular helper cell; NOS, not otherwise specified; ALK,anaplastic lymphoma kinase; ALCL, anaplastic large cell lymphoma; EBV, Epstein barr virus.