Table 4.

Multivariate Cox regression analysis of prognostic factors associated with 28-day mortality in patients with confirmed SARS-CoV-2 infection

Variable	Multivariable Cox’s proportional hazard model			Multivariable Cox’s proportional hazard model using backward stepwise selection based on the Wald statistic
	HR	95% CI for HR	p value	HR	95% CI for HR	p value
FANA	2.145	0.783–5.871	0.138	2.645	1.038–6.739	0.042
Age (per 1-year)	1.036	0.991–1.083	0.118	1.052	1.012–1.095	0.011
Pulmonary disease	3.850	1.014–14.62	0.048	3.155	0.970–10.263	0.056
Hypertension	3.374	1.234–9.225	0.018	2.965	1.280–6.867	0.011
Diabetes mellitus	0.818	0.336–1.989	0.658
Procalcitonin ≥ 0.200 ng/mL	1.871	0.632–5.539	0.258
D-dimer ≥ 1.5 ug/mL	1.031	0.357–2.980	0.955
Ferritin ≥ 800 μg/mL	1.327	0.552–3.193	0.527
Blood urea nitrogen > 20 mg/dL	2.834	0.758–10.598	0.122	3.716	1.092–12.642	0.036
NT-pro BNP > 100 ng/L	1.396	0.266–7.330	0.693
Remdesivir	0.387	0.162–0.925	0.033	0.336	0.153–0.737	0.006
Anticoagulant	1.263	0.434–3.675	0.668

The above covariates were included in the multivariable Cox’s proportional hazard model, and they showed a p value ≤ 0.1 in univariate Cox’s proportional hazard model.

SARS-CoV-2, severe acute respiratory syndrome coronavirus 2; HR, hazard ratio; CI, confidence interval; FANA, fluorescent antinuclear antibody; NT-pro BNP, N-terminal pro-brain natriuretic peptide.