FIGURE 1.

Overview of the included health technology assessment (HTA) reports and clinical guidelines. The green, yellow, and red circles represent the HTA reports with a positive, restricted, or negative recommendation, respectively. The color‐gradient arrows represent the HTA reports that turned from negative or restricted to a more positive recommendation, or from a positive or restricted to a more negative recommendation after reassessment. DE, Germany; EU, European Union; FR, France; HTA, health technology assessment; MS, multiple sclerosis; NL, the Netherlands; PL, Poland; SE, Sweden; UK, United Kingdom.