FIGURE 3.

Anatomical location of areas left 8Av and 46. Demonstrates the similarities in location between left areas 46 and 8Av and the large differences in functional connections. Left area 46 has been suggested to be the target for depression treatment, area 8Av is immediately posterior to it, and is part of a different large‐scale brain network, and seems to be a promising anxiety target (Sandhu et al., 2021). Our results demonstrate consistent functional abnormalities associated with left area 8 Av, not left area 46, in our anxiety patients, which is consistent with previous literature which demonstrated that stimulation of an area similar to left 8 Av has been shown to mediate anxiosomatic symptoms, while stimulation of the region anterior to it, left 46, mediated dysphoric (Siddiqi et al., 2020).