Fig. 2. Co-crystal structures of the SARS-CoV-2 main protease active site.
a, The inhibitor ensitrelvir (PDB: 7VU6) is bound18. b, The inhibitor nirmatrelvir (PDB: 7RFS) is bound25. The colours indicate the various binding pockets following the standard Schechter and Berger nomenclature for proteases254: P1′ (orange), P1 (yellow), P2 (blue) and P3–5 (cyan). SARS-CoV-2, severe acute respiratory syndrome coronavirus 2.