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. 2023 May 12:1–19. Online ahead of print. doi: 10.1038/s41573-023-00692-8

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Fig. 3 — The free (unbound) drug plasma concentration (blue) is depicted, including the maximum drug concentration (C_max) and minimum drug concentration (C_min) at steady state. The 90% effective concentration (EC₉₀; red dotted line), the concentration at which 90% inhibition of viral replication is observed in cellular antiviral assays, is corrected for plasma protein binding. BID, twice daily.