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. 2023 May 12:1–19. Online ahead of print. doi: 10.1038/s41573-023-00692-8

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Fig. 4 — After the initial primary enzymatic assays, a high-throughput tier 1 cellular assay is used to drive medicinal chemistry, and a lower-throughput tier 2 assay is used to predict human dose. A549-hACE2, A549 cell line overexpressing human angiotensin-converting enzyme 2; HAEC, human airway epithelial cell; iPSC, induced pluripotent stem cell; SARS-CoV-2, severe acute respiratory syndrome coronavirus 2.