Table 7.
Pearson correlation (R) and multivariable linear regression analyses (β±SE) among markers of intraglomerular hemodynamic function and TG concentrations across HDL-TG particles.
| Very Large HDL-TG |
Large HDL-TG |
Medium HDL-TG |
Small HDL-TG |
|||||
|---|---|---|---|---|---|---|---|---|
| R | β±SE | R | β±SE | R | β±SE | R | β±SE | |
| RVR (mm Hg/L/min · 1,000) | R: −0.03 p=0.85 |
−0.33 ± 1.23 p=0.79 |
R: 0.04 p=0.83 |
−0.02 ± 0.22 p=0.93 |
R: 0.22 p=0.19 |
0.20 ± 0.16 p=0.22 |
R: 0.27 p=0.10 |
0.35 ± 0.19 p=0.07 |
| GFR (mL/min) | R: 0.20 p=0.16 |
4529.10 ± 3366.30 p=0.19 |
R: −0.06 p=0.69 |
−192.20 ± 603.80 p=0.75 |
R: 0.12 p=0.42 |
338.50 ± 452.20 p=0.46 |
R: 0.34
p=0.01 |
1157.80 ± 540.10
p=0.04 |
| RPF (mL/min) | R: 0.14 p=0.41 |
4047.60 ± 13556.00 p=0.77 |
R: 0.01 p=0.95 |
−853.70 ± 2464.90 p=0.73 |
R: 0.08 p=0.66 |
−108.40 ± 1837.40 p=0.95 |
R: 0.15 p=0.39 |
684.20 ± 2171.00 p=0.75 |
| PGLO (mm Hg) |
R: 0.34
p=0.04 |
1474.41 ± 774.94 p=0.07 |
R: 0.09 p=0.60 |
45.73 ± 148.51 p=0.76 |
R: 0.23 p=0.17 |
107.11 ± 109.04 p=0.33 |
R: 0.41
p=0.01 |
246.31 ± 123.51 p=0.05 |
| RA (dyne · sec · cm−5) | R: −0.22 p=0.18 |
−88543.90 ± 57670.40 p=0.13 |
R: −0.8 p=0.64 |
−9087.60 ± 10751.30 p=0.40 |
R: 0.13 p=0.44 |
5359.10 ± 8033.20 p=0.51 |
R: 0.17 p=0.32 |
11249.90 ± 9362.50 p=0.24 |
| RE (dyne · sec · cm−5) |
R: 0.37
p=0.02 |
75778.20 ± 37794.10 p=0.05 |
R: 0.17 p=0.31 |
4936.80 ± 7242.00 p=0.50 |
R: 0.22 p=0.19 |
4831.00 ± 5360.20 p=0.37 |
R: 0.33
p=0.04 |
9748.10 ± 6187.10 p=0.13 |
| UACR (mg/g) | R: 0.16 p=0.27 |
17.41 ± 75.32 p=0.82 |
R: −0.04 p= 0.76 |
−16.33 ± 13.04 p=0.22 |
R: 0.23 p=0.11 |
9.01 ± 9.90 p=0.37 |
R: 0.46
P<0.001 |
35.30 ± 11.28
p=0.003 |
| YKL-40 (ng/mL) |
R: 0.44
p=0.001 |
103.78 ± 36.83
p=0.01 |
R: 0.30
p=0.03 |
11.87 ± 6.81 p=0.09 |
R: 0.44
p=0.002 |
13.78 ± 4.88
p=0.01 |
R: 0.47
p<0.001 |
18.79 ± 5.97
p=0.003 |
| SBP (mm Hg) | R: 0.07 p=0.64 |
203.43 ± 796.80 p=0.80 |
R: −0.07 p=0.64 |
−102.24 ± 139.55 p=0.47 |
R: 0.17 p=0.22 |
101.15 ± 104.59 p=0.34 |
R: 0.35
p=0.01 |
288.25 ± 124.48
p=0.03 |
| DBP (mm Hg) | R: −0.00 p=0.98 |
−446.84 ± 938.28 p=0.64 |
R: −0.09 p=0.55 |
−151.03 ± 164.07 p=0.36 |
R: 0.13 p=0.37 |
60.07 ± 124.33 p=0.63 |
R: 0.31
p=0.03 |
257.45 ± 150.53 p=0.09 |
Multivariable linear regression analyses adjusted for age, sex, and HbA1c. Multivariable linear regression results indicate the degree of change in the marker of function for every 1 mmol/L increase in HDL-TG (i.e., for every 1mmol/L increase in very large HDL-TG, there is a 4529.10 ± 3366.30 increase in GFR). Bold font indicates statistical significance (p<0.05).
Abbreviations: HDL, high-density lipoprotein; TG, triglycerides; RVR, renal vascular resistance; GFR, glomerular filtration rate; RPF, renal plasma flow; PGLO, intraglomerular pressure; RA, afferent arteriolar resistance; RE, efferent arteriolar resistance; UACR, urinary albumin to creatinine ratio; YKL-40, chitinase-3-like protein; SBP, systolic blood pressure; DBP, diastolic blood pressure.