Table 2.
Comparison of different logistic regression models for response to TNFi, comparing grouped responders (moderate and good) and non-responders at 3-month follow-up, dichotomised based using high (75th) and low (25th) concentrations of MRP8/14 or CRP
| Responses categories calculated using: | ||||||||||||
| 4-component DAS28 | 3-component DAS28 | 2-component DAS28 | ||||||||||
| Model | Cases | OR (95% Cl) | Model fit (pseudo R2) | P value | Cases | OR (95% Cl) |
Model fit (pseudo R2) | P value | Cases | OR (95% Cl) | Model fit (pseudo R2) | P value |
| Low vs high MRP8/14 (µg/mL) | 218 | 1.22 (0.62 to 2.38) |
0.0015 | 0.564 | 241 | 1.92 (1.04 to 3.54) |
0.017 | 0.037 | 241 | 2.03 (1.09 to 3.78) |
0.020 | 0.025 |
| Low vs high MRP8/14 adjusted for pre-treatment CRP | 218 | 1.10 (0.53 to 2.30) |
0.0033 | 0.795 | 241 | 1.53 (0.78 to 2.98) |
0.026 | 0.21 | 241 | 1.60 (0.82 to 3.15) |
0.030 | 0.171 |
| Low vs high CRP only (mg/L) | 215 | 1.64 (0.78 to 3.4) |
0.0092 | 0.188 | 234 | 3.79 (1.81 to 7.93) |
0.062 | <0.001 | 234 | 3.58 (1.74 to 7.35) |
0.058 | <0.001 |
| Low vs high CRP adjusted for pre-treatment MRP8/14 | 215 | 1.79 (0.79 to 4.06) |
0.011 | 0.163 | 234 | 4.11 (1.83 to 9.25) |
0.063 | 0.001 | 234 | 3.73 (1.70 to 8.19) |
0.059 | 0.001 |
Response categorises were calculated using 4 components, 3 components or 2 components.
CRP, C reactive protein; DAS28, disease activity scores in 28-joints; TNFi, tumour necrosis factor inhibitor.