Table 3.

Multivariable analysis of clinical and pathologic parameters available prior definitive treatment for predicting recurrence and overall death in the 125 patients with cM0 primary urethral carcinoma

RFS			OS
Variable	Hazard ratio (95 %-CI)	p value	Hazard ratio (95 %-CI)	p value
Clinical tumor stage	2.04	0.40	1.17	0.85
≥cT3 versus ≤cT2	(0.41–13.09)		(0.19–5.69)
Clinical nodal stage	48.64	<0.001	9.80	0.026
cN+ versus cN0/cNX	(6.96–509.50)		(1.31–92.37)
Tumor location	10.32	<0.001	1.70	0.47
Proximal versus distal	(2.47-72.91)		(0.41–8.80)
Tumor grade	1.11	0.86	4.11	0.08
G3 versus G1/G2	(0.31–4.03)		(0.84–24.97)
Histology	0.70	0.46	1.41	0.56
UC versus non-UC	(0.27–1.80)		(0.44–4.89)
Gender	2.70	0.08	1.71	0.39
Male versus female	(0.89–9.16)		(0.50–6.36)
Age	7.17	0.001	1.96	0.31
≥65 years versus <65 years	(2.18-26.33)		(0.52–7.48)
Prior history of malignoma	1.05	0.94	2.14	0.27
Present versus absent	(0.25–4.07)		(0.55–9.03)

Bold values indicate statistically significant difference