Figure 1. (A) Relative expression levels of let-7b-3p in control versus methamphetamine-addicted brain tissues. (B) ROC analysis of let-7b-3p in methamphetamine versus control samples (NAc and VTA regions). Let-7b-3p cooperative power to discriminate two sets of samples composed of 21 methamphetamine and 21 control samples. (C) PPI network of commonly deregulated let-7b-3p targets. Pink: experimentally determined (known interactions); blue: from curated databases (known interactions); yellow: text mining; green: gene neighborhood (predicted interactions); black: co-expression. The interaction score was set to high confidence of 0.49. ***p<0.01.
