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. 2023 Apr 10;29(6):680–690. doi: 10.1177/13524585231162262

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© The Author(s), 2023

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 1. — Assessment of co-localization between PRLs and SELs and identification of PRL+/SEL− and SEL+/PRL− phenotypes. (a) T1-weighted image. (b) T2-weighted image. (c) Filtered SWI-phase image. (d) T2-lesion mask at baseline. (e) Manual PRL annotation at week 72. (f) T2-associated PRL at week 72. (g) SELs detected based on interval from baseline to week 72. (h) Voxelwise overlap of T2-associated PRLs and SELs (red = PRL only, blue = SEL only, yellow = both). (i) Co-localized PRL+/SEL+ mask (dark red). (j) Co-localized SEL+/PRL+ mask (dark blue). (k) PRL+/SEL− lesions (light red). (l) SEL+/PRL− lesions (light blue). Note that lesion boundaries are slightly different in (i) and (j) due to differences in PRL and SEL detection methods.

PRL: paramagnetic rim lesion; SEL: slowly expanding lesion; SWI: susceptibility-weighted imaging; T2-assoc PRL: T2-lesion associated with a given paramagnetic rim.