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. 2023 Apr 10;29(6):680–690. doi: 10.1177/13524585231162262

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© The Author(s), 2023

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 2. — Evolution of tissue damage in PRLs and SELs based on lesion-level correspondence. PRLs are subcategorized into those that overlap with SELs (PRL+/SEL+, solid red line) and those that do not (PRL+/SEL−, dashed red line). SELs are subcategorized into those that overlap with PRLs (SEL+/PRL+, solid blue line) and those that do not (SEL+/PRL−, dashed blue line). Overall T2 lesions are included as a reference (solid green line). Least-squares estimates and [95%] confidence intervals of change over time are derived from MMRM with weeks since baseline modeled as linear continuous. (A) nMTR, (B) nT1, (C) RD, and (D) FA.

FA: fractional anisotropy; MMRM: mixed-effect model of repeated measurement; nMTR: normalized magnetization transfer ratio; nT1: normalized T1 intensity; PRL: paramagnetic rim lesion; RD: radial diffusivity; SEL: slowly expanding lesion.