Table 2.

Comparison of baseline and longitudinal change in tissue damage in SELs that do and do not co-localize with PRLs.

	nMTR		nT1		RD		FA
	EST	P value	EST	P value	EST	P value	EST	P value
Baseline
SEL+/PRL+	−1.3715	n/a	−0.0816	n/a	0.9701	n/a	0.3173	n/a
SEL+/PRL−	−0.8121	n/a	0.1064	n/a	0.9250	n/a	0.3097	n/a
T2 lesion	−0.5669	n/a	0.1955	n/a	0.8579	n/a	0.3417	n/a
Difference at baseline
(SEL+/PRL+) − (SEL+/PRL−)	−0.5594	<0.0001	−0.1880	0.0074	0.0451	0.1078	0.0075	0.5967
(SEL+/PRL+) − (T2 lesion)	−0.8046	<0.0001	−0.2771	0.0034	0.1122	0.0031	−0.0244	0.1897
(SEL+/PRL−) − (T2 lesion)	−0.2452	0.0399	−0.0891	0.2305	0.0671	0.0249	−0.0319	0.0304
Change over 72 weeks
SEL+/PRL+	−0.1444	0.0009	−0.1867	<0.0001	0.0912	<0.0001	−0.0182	0.0001
SEL+/PRL−	−0.0776	0.0001	−0.1370	<0.0001	0.0471	<0.0001	−0.0145	<0.0001
T2 lesion	0.0113	0.8054	−0.0441	0.0520	0.0161	0.1236	−0.0015	0.7594
Difference in change over 72 weeks
(SEL+/PRL+) − (SEL+/PRL−)	−0.0668	0.1618	−0.0497	0.0348	0.0441	<0.0001	−0.0036	0.4690
(SEL+/PRL+) − (T2 lesion)	−0.1557	0.0140	−0.1427	<0.0001	0.0751	<0.0001	−0.0167	0.0129
(SEL+/PRL−) − (T2 lesion)	−0.0889	0.0762	−0.0929	0.0002	0.0310	0.0065	−0.0130	0.0146

Overall T2 lesions are used as the reference. Lower values of nMTR, nT1, and FA, and higher values of RD, signify worsening tissue integrity. Baseline estimates were derived from an MMRM with weeks since baseline modeled as categorical. Change over 72 weeks was derived from an MMRM with weeks since baseline modeled as linear continuous. When looking at change over 72 weeks, statistical significance relates to difference from 0 (no change), whereas for difference at baseline and difference in change over 72 weeks statistical significance relates to differences between lesion subtypes. Bold numbers indicate P-value < 0.05.

EST: estimate; FA: fractional anisotropy; MMRM: mixed-effect models of repeated measurement; n/a: not applicable; nMTR: normalized magnetization transfer ratio; nT1: normalized T1.