Table 1.

Sapporo classification criteria [2]

Clinical criteria
1. Vascular thrombosis
≥1 Clinical episodes of arterial, venous, or small vessel thrombosis
2. Pregency morbidity
≥1 Unexplained deaths of a morphologically normal fetus ≥ 10th week of gestation
≥1 Premature births of a morphologically normal neonate < 34th week of gestation due to: - eclampsia - severe pre-eclampsia - placental insufficiency
≥3 Unexplained consecutive spontaneous abortions < 10th week of gestation (with exclusion of maternal anatomic, hormonal or chromosomal abnormalities)
Laboratory criteria: on 2 or more occasions at least 12 weeks apart
LA present in plasma
aCL of IgG and/or IgM isotope in serum or plasma, present in medium or high titer (> 40 GPL or MPL, or > the 99th percentile)
Anti-β2GP1 of IgG and/or IgM isotope in serum or plasma (in titer > the 99th percentile)