Table 1.
Base and amino acid substitutions/deletions in isolated SARS-CoV-2 after COVID-19 symptoms began.
| Base substitution and deletion* |
G910A |
T911A, C912A |
C2197T |
T3161C |
6513-6515 Del |
G8868A |
G23048A |
C24054T |
G24521T |
T28417C |
|---|---|---|---|---|---|---|---|---|---|---|
| Amino acid substitution | － | S36 N in NSP2 | － | S148P in NSP3 | S1265del and L1266I in NSP3 | G105D in NSP4 | G496S in S | A831V in S | V987F in S | I45T in ORF9b |
| Day 47 | － | － | － | － | － | － | ● | － | － | ● |
| Day 60 | － | － | － | － | ● | － | ● | － | － | ● |
| Day 66 | － | － | － | － | ● | － | ● | ● | － | ● |
| Day 71 | － | － | － | － | ● | － | ● | ● | － | ● |
| Day 78 | － | － | － | － | ● | － | － | － | － | － |
| Day 92 | ○ | ● | － | － | ● | － | ● | ● | － | ● |
| Day 100 | － | － | ○ | ● | ● | ● | － | － | ● | － |
Footnote: Remdesivir administration: first, between day 1–5 (five days); second, from day 72–81 (10 days); third, from day 102–111 (10 days). *These base substitutions and a deletion are relative to the reference strain Wuhan-Hu-1/2019 (GenBank accession number MN908947).
Abbreviations: Del, deletion; NSP, non-structural protein; S, spike protein; ORF, open-reading frame; －, no substitution detected; ○, synonymous mutation; ●, non-synonymous mutation.