Figure 2.

Reciprocal interaction between circadian regulation, TLR signaling and αSyn mediated neurodegeneration. In vertebrates, TLR expression is rhythmically controlled and in turn influences molecular and behavioral rhythms. Circadian clocks control the neuroinflammatory response leading to neuronal damage, which, in turn, causes circadian dysfunctions. The rhythmic regulation of TLRs could result in a daily variation of the downstream signaling cascades, conferring a circadian signature on αSyn-mediated neuronal degeneration. Created with BioRender.com.