Table 1.
Baseline patient characteristics. fRNB = focal radiation necrosis of the brain, WHO-PS = World Health Organization Performance Status.
| Characteristics | No. of Patients (%) Total (n = 13) |
|---|---|
| Median age, years (range) | 52 (33–68) |
| Sex | |
| Male | 7 (54%) |
| Female | 6 (46%) |
| Primary disease | |
| Melanoma | 6 (46%) |
| Non-small cell lung carcinoma | 3 (23%) |
| Breast cancer | 1 (8%) |
| Renal cell carcinoma | 1 (8%) |
| Medulloblastoma | 1 (8%) |
| Arteriovenous malformation | 1 (8%) |
| WHO-PS at inclusion | |
| 0 | 10 (77%) |
| 1 | 3 (23%) |
| Number of fRNB locations | |
| 1 | 9 (69%) |
| 2 | 3 (23%) |
| 3 | 1 (8%) |
| Prior radiation therapy | |
| Stereotactic radiosurgery | 6 (46%) |
| Stereotactic radiotherapy | 3 (23%) |
| Both | 4 (31%) |
| Corticosteroid treatment prior to initiation of bevacizumab | |
| Yes | 5 (39%) |
| No | 8 (62%) |
| Diagnosis of fRNB based on MRI supported by | |
| Histopathological examination of biopsy | 6 (46%) |
| 18F-FDG PET-CT | 6 (46%) |
| MRI-only | 3 (23%) |
| Symptoms at baseline | |
| Headache | 1 (8%) |
| Epileptic seizures | 6 (46%) |
| Focal neurological deficit | 9 (69%) |