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. 2023 May 5;15(9):2626. doi: 10.3390/cancers15092626

Figure 4.

Figure 4

Depletion of neutrophils suppresses brain metastasis in vivo (A) Injection timeline and scheme. (B) PMBCs from mice treated with IgG or Ly6G antibodies were stained with neutrophil marker LY6G and CD11b antibodies and analyzed by flow cytometry. (C) Quantification of Figure B. Brain metastasis-free survival (Kaplan–Meier analysis) and brain bioluminescence of (D). SKBrM3 cells and (F) 231BrM cells after IC injection in mice treated with IgG or Ly6G antibody. (E,G) Representative picture of mice at day 0 and endpoint after IC injection (* p  <  0.05, ** p  <  0.01, or *** p < 0.001).