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. 2023 Apr 27;15(9):2517. doi: 10.3390/cancers15092517

Figure 1.

Figure 1

Effects of the AIs, Ana (A,B), Let (C,D), and Exe (E,F), CBD, and their combinations on MCF-7aro cell viability, as well as on the viability of HFF-1 cells (H). MCF-7aro cells were stimulated with T (1 nM) and treated with the AIs (10 µM), CBD (1 and 5 µM), or their combinations, over 3 or 6 days. Cells treated only with T were used as control, representing 100% of cell viability. After the 3 days of treatment, the LDH assay was also performed (G). The HFF-1 cells were subjected to the same concentrations of AIs and CBD for 6 days (H) and cells without any treatment were considered as control, representing 100% cell viability. The results are presented as mean ± SEM of at least three independent experiments performed in triplicate. Statistically significant differences between cells treated with compounds and T-treated cells (control) are expressed as *** (p < 0.001), while differences between the combinations and each AI alone are represented as ## (p < 0.01) and ### (p < 0.001), and the differences between the combinations and CBD as $$ (p < 0.01) and $$$ (p < 0.001).