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. 2023 Apr 27;15(9):2517. doi: 10.3390/cancers15092517

Figure 2.

Figure 2

Analysis of MCF-7aro cell death. Effects of the AIs, Ana, Let, and Exe, as well as of CBD and their combinations on the activities of caspase-7 (A,D), caspase-8 (B), and caspase-9 (C). Cells were stimulated with T (1 nM) and treated with the AIs (10 µM), CBD (1 and 5 µM), or their combinations, for 2 days. Cells treated with Exe, CBD, and their combination were also treated with CDX (1 µM). Cells treated only with T were used as control, while STS-treated cells were considered as positive control. Statistically significant differences between treated cells and T (control) are expressed as * (p < 0.05), ** (p < 0.01) and *** (p < 0.001), while differences between the combinations and each AI alone are represented as # (p < 0.05), ## (p < 0.01) and ### (p < 0.001), and the differences between the combinations and CBD as $ (p < 0.05), $$ (p < 0.01) and $$$ (p < 0.001).