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. 2023 Apr 29;15(9):2547. doi: 10.3390/cancers15092547

Table 1.

Summary of the studies describing the recent developments in Artificial Intelligence systems.

Study
(Year)
Study Type Objective Data type AI Results Application Limitations
Mohan et al.,
2022
Meta-analysis
11 studies 2001–2020
Overall performance of AI in:
-Diagnosis and characterization of solid PL
-Differentiate PC from non-neoplastic tissue
-Differentiate malignancy from CP
-Diagnosis of PC
-EUS elastography
-EUS images
-EUS—videos
-CEH-EUS
Fractal-based quantitative analysis
NN algorithm
SVM
-Overall accuracy 85.8%
-Sens 91.8%
-Spec 84.6%
-PPV 87.4%
-NPV 91.4%
-Heterogeneity 57%
Superior diagnostic results with the combination of AI and newer core-biopsy needles in EUS evaluation of solid masses -Heterogeneity
-Absence of prospective data
Yu et al.,
2022
Case report Guiding punction of pancreatic masses by differentiating cancerous, non-cancerous, and necrotic regions N/A Deep CNN Improving the diagnostic accuracy of EUS FNA
Zhang et al.,
2020
Cross-over
8 participants
BP-MASTER®
-Test the performance of classifying the previously learned stations of pancreatic EUS
-Pancreatic tissue and blood vessel segmentation
-EUS images
-EUS videos
Deep learning -Classification accuracy 86%
-Comparable accuracy between endoscopists and AI
-Improvement of trainee’s accuracy for classification and segmentation
Shortening the pancreatic EUS learning curve
Improving EUS quality control
-Duodenal bulb station non studied
Goyal et al., 2022 Systematic review
11 studies
Study the effectiveness of AI with EUS in the diagnosis of pancreatic cancer
-Differentiating PC from CP
-Differentiating malignant from benign IPMNs
-Retrospective EUS images and videos
-Real time collected EUS images
ANN
CNN
SVM
Performance in recognition of pancreatic malignancy:
-Sens 83–100%
-Spec 50–99%
-Accuracy 80–97.5%
-PC vs. CP
ANN
-Sens 88–100%
-Spec 50–94%
-SVM
-Sens 96%
-Spec 93%
-Accuracy 94%
CNN
-Sens 90%
-Spec 75%
Benign vs. malignant IPMNs
CNN
-Sens 95.7%
-Spec 92.6%
-Accuracy 94%
-Improvement of pancreatic malignancy recognition even in presence of chronic pancreatitis
-SVM method simpler and highly performant
Ishikawa et al.,
2022
Retrospective -Study the usefulness of AI in predicting the EUS-FNB sample quality for histopathological examination -Stereomicroscopic images of EUS-FNB specimens CNN and deep learning
Contrastive learning
-AI evaluation using contrastive learning is comparable to MOSE performed by EUS experts
-Diagnostic accuracy with deep learning not as high as MOSE performed by experts
Increasing the objectivity of the evaluation Small sample size

AI artificial intelligence, ANN artificial neuronal networks, CEH-EUS contrast enhanced EUS, CNN convolutional neural networks, CP chronic pancreatitis, EUS endoscopic ultrasound, FNA fine needle aspiration, FNB fine needle biopsy, IPMN intraductal papillary mucinous neoplasm, MOSE macroscopic on-site evaluation, NN neural network, NPV negative predictive value, PC pancreatic cancer, PL pancreatic lesions, PPV positive predictive value, Sens sensitivity, Spec specificity, SVM Support vector machine.