Table 2.

Areas for future research in the prevention and treatment of obesity-associated breast cancer.

Prevention

Identifying the metabolic pathways that drive breast cancer for the development of biomarkers to predict those at increased risk Identifying the molecular mechanisms underlying the relationship between pre-menopausal patients and obesity that reduce breast cancer risk Improving risk prediction models that incorporate body composition parameters to predict breast cancer risk Improving lifestyle interventions and pharmacologic strategies for weight management for primary, secondary, and tertiary breast cancer prevention

Treatment

Identifying the metabolic pathways that drive breast cancer for the development of novel therapies and biomarkers that predict response to treatment Identifying targetable metabolic pathways that result in increased endocrine therapy resistance in patients with obesity Improving risk prediction models that incorporate body composition parameters to predict response to therapy Improving chemotherapy dosing strategies to reflect body composition in patients with obesity Optimizing the selection, dosing, and duration of hormone therapy for patients with obesity Improving strategies for the prevention and treatment of cardiometabolic adverse effects in patients with obesity Increasing the number of clinical trials focused on patients with obesity