Table 1.
Baseline characteristics of the study population.
| Patient Characteristics | Intrahepatic Cholangiocarcinoma |
Hepatocellular Carcinoma |
Liver Secondary Tumors | p Value |
|---|---|---|---|---|
| Number of patients | 65 | 65 | 65 | ns |
| Clinical parameters | ||||
| Age | ||||
| Mean ± SD | 64.42 ± 9.23 | 65.57 ± 6.49 | 63.06 ± 9.78 | ns |
| Range | 41–84 | 51–80 | 39–85 | |
| Sex, n (%) | ||||
| Male | 34 (52.3) | 50 (76.92) | 31 (47.69) | ns |
| Female | 31 (47.69) | 15 (23.08) | 34 (52.3) | |
| Environment, n (%) | ||||
| Urban | 35 (53.85) | 45 (69.23) | 50 (76.92) | 0.0013 |
| Rural | 30 (46.15) | 20 (30.77) | 15 (23.08) | |
| Associated diseases, n (%) | ||||
| Obesity | 6 (9.23) | 8 (12.3) | 9 (13.84) | ns |
| Diabetes mellitus | 13 (20) | 15 (23.07) | 13 (20) | ns |
| Liver steatosis | 16 (24.61) | 15 (23.07) | 13 (20) | ns |
| Chronic Hepatitis | ||||
| HBV | 7 (10.77) | 11 (16.92) | 1 (1.53) | 0.01 |
| HCV | 10 (15.38) | 31 (47.69) | 2 (3.07) | <0.001 |
| Alcohol abuse | 3 (4.61) | 15 (23.07) | 3 (4.61) | <0.001 |
| Liver cirrhosis | 12 (18.46) | 53 (81.53) | 4 (61.53) | <0.001 |
| Ethanolic | 3 (4.61) | 14 (21.53) | 1 (1.53) | <0.001 |
| HBV | 3 (4.61) | 8 (12.3) | - | nc |
| HCV | 5 (7.69) | 29 (44.61) | 1 (1.53) | <0.001 |
| Autoimmune | 1 (1.53) | - | - | ns |
| Metabolic | - | 1 (1.53) | - | nc |
| Idiopathic | 1 (1.53) | 3 (4.61) | 1 (1.53) | nc |
| Overall survival (months) | ||||
| Mean ± SD | 9.25 ± 9.65 | 31.22 ± 24.9 | 31.85 ± 44.47 | <0.001 |
| Range | 0.1–38.66 | 0.16–84 | 0.5–192 | |
| Serum tumoral markers | ||||
| AFP | 72.59 ± 139.51 | 95.74 ± 151.93 | 24.84 ± 90.93 | nc |
| CEA | 8.84 ± 13.32 | 3.65 ± 4.02 | 40.64 ± 58.23 | nc |
| CA 19-9 | 202.14 ± 162.71 | 98.36 ± 95.12 | 146.84 ± 170.3 | nc |
| Morphologic parameters | ||||
| Tumor size (cm) | ||||
| Mean ± SD | 8.05 ± 3.58 | 5.45 ± 4.11 | 4.86 ± 3.81 | <0.001 |
| Range | 0.6–16 | 1.3–19 | 0.5–18 | |
| Number of tumors, n (%) | ||||
| Solitary | 26 (40) | 28 (43.07) | 5 (7.7) | <0.001 |
| Multiple | 39 (60) | 37 (56.92) | 60 (92.3) | |
| Tumor differentiation, n (%) | ||||
| Good | 12 (18.46) | 6 (9.24) | 16 (24.61) | <0.001 |
| Moderate | 23 (35.38) | 45 (69.24) | 17 (26.16) | |
| Poor | 15 (23.07) | 3 (4.62) | 8 (12.31) | |
| N/A | 14 (21.53) | 11 (16.9) | 24 (36.92) | |
| Tumor infiltrating lymphocytes count, n (%) | ||||
| Low | 38 (58.46) | 26 (40) | 23 (35.38) | <0.001 |
| Moderate | 17 (26.15) | 5 (7.69) | 13 (20) | |
| Abundant | 0 | 1 (1.54) | 1 (1.54) | |
| Absent | 3 (4.62) | 0 | 0 | |
| N/A | 7 (10.77) | 33 (50.77) | 28 (43.08) | |
| Number of immunohistochemical stains used (Mean ± SD) | 8 ± 3 | 4 ± 1.67 | 6 ± 3.62 | nc |
nc = not calculated due to low sample size, ns = not significant.