Table 3.
Univariate and multivariate analysis of overall survival in intrahepatic cholangiocarcinoma (iCCA) patients.
| OS | Univariate Analysis | Multivariate Analysis | ||||
|---|---|---|---|---|---|---|
| HR | 95% CI | p | HR | 95% CI | p | |
| Age | 0.97 | 0.94–1 | 0.076 | |||
| Tumor number (multiple vs. single) | 1.42 | 0.82–2.46 | 0.208 | |||
| Liver cirrhosis (yes vs. no) | 0.93 | 0.46–1.85 | 0.828 | |||
| Immune cell infiltrate (yes vs. no) * | 2.68 | 1.38–5.2 | 0.004 | 3.64 | 1.67–7.9 | 0.001 |
| Tumor differentiation ** | 1.11 | 0.56–2.18 | 0.771 | |||
| CDX2 (positive vs. negative) | 1.84 | 0.88–3.85 | 0.108 | |||
| CK7 negative (yes vs. no) *** | 1.82 | 0.92–3.6 | 0.087 | 2.42 | 1.1–5.33 | 0.028 |
| CK19 negative (yes vs. no) # | 0.48 | 0.22–1.03 | 0.06 | |||
* we compared intense and moderate with low or negative; ** we compared well-differentiated with moderate and poor differentiation; *** patients CK7-negative or with a weak staining were compared with moderate or intense staining; # patients CK19-negative or with a weak staining were compared with moderate or intense staining; p = level of significance; CI = confidence interval; HR = hazard ratio.