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Unveiling the crucial roles of HSPB1 (HSP27) in combatting mutant proteins linked to ALS. The figure illustrates how HSP27 is critical in mitigating toxicity-associated effects of misfolded aggregates during the progression of ALS. HSP27 is found to inhibit the toxic amyloidosis of mutant aggregation-prone proteins during ALS (A) and enhance the cytoprotective response against protein aggregation-associated toxicities (B). In addition, it can also act as an anti-apoptotic protein (C).
