Figure 1.

Schematic display of immunization, treatment and analysis schedule. (A) Prevention model shows IVIg treatment (green) during the onset of antibody formation by Dsg3 immunization (red) at week 0 and week 2 (A1) and week 4 (A2, A3) (grey boxes). (B) Quasi-therapeutic model displaying a weekly IVIg application at weeks 4–8, starting at d14 after booster Dsg3 immunization at week 2 (colored boxes). Abbreviations: i.p = intraperitoneal; IVIg = high-dose intravenous immunoglobulin; Dsg3 = desmoglein 3; W = week; d = day.