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Schematic distribution of ESR1 mutations identified with LNA-clamp ddPCR. FF tissue from 212 primary tumors was analyzed with LNA-clamp ddPCR. Twenty-six mutations with VAF < 0.1% (blue) and two mutations with VAF ≥ 0.1% (red) were detected in twenty-seven patients. The number in each lollipop represents the patient number. AF-1—activation function-1, DBD—DNA-binding domain, HR—hinge region, AF-2—activation function-2, and LBD—ligand-binding domain.
