FIG. 4.
Effects of anti-IL-12 treatment on parasite loads in footpads of C57BL/6 mice infected with 106 (A) or 102 (B) L. major metacyclic promastigotes. Mice were injected with anti-IL-12p40 (c17.8; rat IgG1) (◊) or with anti-β-galactosidase control (GL113) (□). Results are expressed as the geometric mean number of viable amastigotes per milligram of tissue ± 1 standard deviation; 4 mice per group were used. The asterisk indicates the significant difference between values at the indicated time point (P < 0.05).