Figure 4.

Antitumor effect of Euterpe oleracea seed extract in in vitro and in vivo assays. (A) Tumor weight reduction of the Ehrlich solid tumor due to treatments with açaí seed extract and cyclophosphamide. (B) Kinetic curve of paw volume during the tumor development. The groups treated with seed extract at 100 mg/kg (SE100), 200 mg/kg (SE200), and 400 mg/kg (SE400) were compared with the group without solid tumor (Sham), represented by “a”; the tumor-inoculated group treated with saline (CTL−) is represented by “b”, and the tumor-inoculated group treated with cyclophosphamide at 20 mg/kg (CTL+) is represented by “c”. The statistical difference was represented by one letter for p < 0.05, two letters for p < 0.01, and three letters for p < 0.001 (ANOVA and Tukey’s post-hoc test). (C) Area under the curve (AUC) for each individual tumor growth curve shown in Figure 3B. Data represent the mean ± S.D. * p < 0.01 and ** p < 0.001 compared with negative control group (CTL−) (ANOVA and Tukey´s post-hoc test).