Table 4.
Histological scores in tumor tissue and matched normal tissues in all experimental groups.
| Histological Features |
Scores | Animal Groups | |||||
|---|---|---|---|---|---|---|---|
| Sham | Ehrlich+ | ||||||
| CTL− | CTL+ | SE (mg/kg) | |||||
| 100 | 200 | 400 | |||||
| Nuclear pleomorphism |
0 | 6 | - | - | - | - | - |
| + | - | - | - | - | - | - | |
| ++ | - | - | 4 | 3 | 1 | 2 | |
| +++ | - | 6 | 2 | 3 | 3 | 3 | |
| Necrosis | 0 | 6 | - | - | - | - | - |
| + | - | 2 | - | - | - | - | |
| ++ | - | 3 | 2 | 2 | 2 | 4 | |
| +++ | - | 1 | 4 | 4 | 2 | 1 | |
| Mitotic figures | 0 | 6 | - | - | - | - | - |
| + | - | - | - | - | - | - | |
| ++ | - | 2 | 5 | 4 | 2 | 5 | |
| +++ | - | 4 | 1 | 2 | 2 | - | |
| Inflammatory infiltrate |
0 | 6 | - | - | - | - | - |
| + | - | - | - | - | - | - | |
| ++ | - | 3 | 2 | 3 | - | 1 | |
| +++ | - | 3 | 4 | 3 | 4 | 4 | |
| Tumor invasion | 0 | 6 | - | - | - | - | - |
| + | - | 3 | - | 1 | - | - | |
| ++ | - | 1 | 2 | - | - | 2 | |
| +++ | - | 1 | 4 | 5 | 4 | 3 | |
Mice without tumor induction (Sham; n = 6); mice with tumors treated with saline (CTL−; n = 6); mice with tumors treated with cyclophosphamide (CTL+); and mice with tumors treated with 100 (SE100; n = 6), 200 (SE200; n = 4), or 400 mg/kg (SE400; n = 5) seed extract. The signal “-” indicates there were no animals with that score. Score intensity was minimal: +, moderate: ++, intense: +++.