Table 6.
Histological scores in hepatic and renal tissues from all experimental groups.
| Organ | Histological Features | Scores | Animal Groups | |||||
|---|---|---|---|---|---|---|---|---|
| Sham | Ehrlich+ | |||||||
| CTL− | CTL+ | SE (mg/kg) | ||||||
| 100 | 200 | 400 | ||||||
| Liver | Mild diffuse vacuolar degeneration |
0 | 6 | - | - | - | - | - |
| + | - | - | - | - | - | - | ||
| ++ | - | - | 4 | 3 | 1 | 2 | ||
| +++ | - | 6 | 2 | 3 | 3 | 3 | ||
| Moderate diffuse vacuolar degeneration |
0 | 6 | - | - | - | - | - | |
| + | - | 2 | - | - | - | - | ||
| ++ | - | 3 | 2 | 2 | 2 | 4 | ||
| +++ | - | 1 | 4 | 4 | 2 | 1 | ||
| Kidney | Mild diffuse vascular congestion |
0 | 6 | - | - | - | - | - |
| + | - | - | - | - | - | - | ||
| ++ | - | 2 | 5 | 4 | 2 | 5 | ||
| +++ | - | 4 | 1 | 2 | 2 | - | ||
| Moderate diffuse vascular congestion |
0 | 6 | - | - | - | - | - | |
| + | - | - | - | - | - | - | ||
| ++ | - | 3 | 2 | 3 | - | 1 | ||
| +++ | - | 3 | 4 | 3 | 4 | 4 | ||
| Mild multifocal vascular congestion |
0 | 6 | - | - | - | - | - | |
| + | - | 3 | - | 1 | - | - | ||
| ++ | - | 1 | 2 | - | - | 2 | ||
| +++ | - | 1 | 4 | 5 | 4 | 3 | ||
Mice without tumor induction (Sham; n = 6); mice with tumors treated with saline (CTL−; n = 6); mice with tumors treated with cyclophosphamide (CTL+); and mice with tumors treated with 100 (SE100; n = 6), 200 (SE200; n = 4), or 400 mg/kg (SE400; n = 5) seed extract. The signal “-” indicates there were no animals with that score. Score intensity was minimal: +, moderate: ++, intense: +++.