Table 3.
Univariate survival analysis using Cox models: Hazard ratios (HR), 95% confidence intervals, and p-values.
| EFS | OS | |||
|---|---|---|---|---|
| HR [95% CI] | p-Value | HR [95% CI] | p-Value | |
| MYCN: A | Ref. | Ref. | Ref. | Ref. |
| NA | 1.49 [0.61; 3.63] | 0.38 | 0.73 [0.23; 2.35] | 0.60 |
| Chemotherapy cycles: 5 | Ref. | Ref. | Ref. | Ref. |
| >5 | 0.96 [0.37; 2.50] | 0.93 | 0.64 [0.18; 2.29] | 0.49 |
| ASCT: No | Ref. | Ref. | Ref. | Ref. |
| Yes | 0.16 [0.02; 1.16] | 0.070 | 0.40 [0.05; 3.08] | 0.38 |
| RDT: No | Ref. | Ref. | Ref. | Ref. |
| Yes | 0.82 [0.38; 1.78] | 0.62 | 1.03 [0.34; 3.08] | 0.96 |
| MRD: No | Ref. | Ref. | Ref. | Ref. |
| Yes | 3.29 [1.54; 7.00] | 0.0020 | 1.99 [0.62; 6.37] | 0.24 |
| Age at diagnosis (y) | 1.13 [0.96; 1.32] | 0.13 | 1.08 [0.82; 1.41] | 0.59 |
| Age at initiation (y) | 1.12 [0.95; 1.31] | 0.18 | 1.05 [0.79; 1.40] | 0.72 |
Legend: ASCT = autologous stem cell transplant; RDT = radiotherapy; MRD = minimal residual disease.