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. 2023 Apr 29;15(9):2548. doi: 10.3390/cancers15092548

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Comparison of consistent and inconsistent epigenotypes in Beckwith–Wiedemann syndrome-associated hepatoblastomas (BWS-HBs). Consistent epigenotypes are characterized by stable and heritable epigenetic modifications that are present in all tissues of an individual’s body and maintained throughout development and aging. Inconsistent epigenotypes, on the other hand, are characterized by dynamic or unstable epigenetic modifications that are present in only some cells of an individual’s body or vary over time.