Figure 1.

Schematic representation of the mechanisms of action of metronomic chemotherapy (mCT) on tumors. mCT is administered continuously using a low dose of chemotherapy for a period of time with no prolonged drug-free interruptions, resulting in effective inhibition of tumor angiogenesis and tumor growth and promoting the anti-tumor immune response. VEGFR, vascular endothelial growth factor; bFGF, basic fibroblast growth factors; PDGF, platelet-derived growth factor; TSP-1, Thrombospondin-1; sVEGFR, soluble vascular endothelial growth factor receptor-1; NK cells, natural killer cells; Treg cell, T regulatory cells. This figure was generated using Servier Medical Art, provided by Servier, and licensed under a Creative Commons Attribution 3.0 unported license.