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Effects of Zol and Dmab on NK cells. In bone marrow, Zol and Dmab exert a stimulatory effect on NK cells, increasing IFNγ release and cytotoxic activity mediated by the release of granzyme (GzmB) and perforin (PFN), which cause cell killing. In gingiva, Zol and Dmab stimulate NK cell cytotoxic activity and inhibit IFNγ secretion, which results in an inhibition of immune cells and the unbalanced activity of OCs and OBs. Created by Biorender (accessed on 28 February 2023).
