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Regulatory network of Nrf2 activity. (A) Mechanisms of Nrf2 inhibition via the canonical Keap1-mediated and the non-canonical GSK3-β/β-TrCP-mediated proteasomal degradation. (B) Simplified scheme of Nrf2 activation via classical oxidant/electrophile-mediated Keap1 inhibition and/or receptor-mediated Keap1 as well as GSK3-β inhibition. (created with BioRender.com).
