TABLE 2.
LSA-1 peptide-driven cytokine production according to age and season
| Cytokine | Children (≤17 yr old)
|
Adults (≥18 yr old)
|
||||
|---|---|---|---|---|---|---|
| Rainy | Dry | P | Rainy | Dry | P | |
| IL-5 | ||||||
| Median (range)a | 65 (0–558) | 44 (0–792) | NS | 84 (0–1,184) | 30 (0–1,345) | NSb |
| No. positive/totalc | 6/13 (46.1) | 9/28 (32.1) | NS | 15/28 (53.6) | 21/56 (37.5) | NSd |
| IL-10 | ||||||
| Median (range) | 201 (21–1,875) | 37 (0–663) | <0.001 | 205 (0–1,562) | 56 (0–1,088) | <0.001 |
| No. positive/total | 14/17 (82.3) | 6/28 (21.4) | <0.001 | 16/24 (66.7) | 10/66 (15.1) | <0.001 |
| IFN-γ | ||||||
| Median (range) | 76 (0–8,000) | 6 (0–2,572) | NS | 275 (0–3,690) | 245 (0–8,000) | NS |
| No. positive/total | 8/25 (32.0) | 12/36 (33.3) | NS | 29/55 (52.7) | 40/76 (52.6) | NS |
| TNF-α | ||||||
| Median (range) | 266 (0–8,681) | 44 (0–792) | 0.002 | 344 (0–3,500) | 37 (0–1,345) | <0.001 |
| No. positive/total | 8/14 (57.1) | 4/24 (16.7) | <0.001 | 14/19 (73.7) | 13/45 (28.9) | 0.001 |
a
Median amount of cytokine produced in picograms per milliliter.
b
Mann-Whitney U test; NS, not significant.
c
A positive response is defined as greater than the mean + 2 SD of North American controls. Values in parentheses represent percent positive.
d
χ2 test.