Figure 5.

Native and denoised PET images of a patient with slightly better lesion detection with native PET. Legend: DL: deep learning processing by SubtlePET^TM. A [¹⁸F]FDG PET/CT exam of a 37-year-old female patient, weight 105 kg, BMI 34 kg/m² and FM 48 kg. She was referred for the follow-up of breast cancer with multiple (strongly) [¹⁸F]FDG avid bone and nodal metastases. In (a) MIP views are illustrated of native (on the left) and denoised PET (on the right). Almost all lesions were detected similarly in both PET modalities. Nonetheless, denoised images appeared less noisy, especially in the liver. Small red arrows in (a) depict a false negative small bone metastasis in denoised PET, further illustrated on axial PET/CT slices in (b) (upward blue arrows). This small low-activity focus corresponds to a lytic bone lesion measuring 4 mm on CT (b, upward blue arrows). This false negative lesion on denoised PET had no clinical impact.