Table 1.
Scavenger receptors that may be involved in the pathogenesis of atherosclerosis.
| Name | Cells | Main Ligands | References |
|---|---|---|---|
| SR-A1 (CD204, SCARA1) | Mf, EC, VSMC | HSP, AGE, PAMP, DNA, oxLDL, acLDL, polyanions, calciproteins, spectrin | [206,213,214,215,216,217] |
| SR-A5 (SCARA5) | EC | PAMP, oxLDL, acLDL, polyanions, ferritin | [216,218,219,220,221] |
| SR-A6 (MARCO) | Мf | PAMP, oxLDL, acLDL, polyanions | [215,216,219,222,223] |
| SR-B1 (CD36L1) | Мf, EC | HDL, oxHDL, oxLDL, acLDL, PAMP, polyanions, carotenoids | [224,225,226] |
| SR-B2 (CD36) | Мf, EC, VSMC, platelets | Phosphatidylserine, oxLDL, AGE, thrombospondin, PAMP, polyanions, FFA, collagen, fibronectin, integrins | [219,227,228,229,230] |
| SR-D1 (CD68) | Мf, monocytes | oxLDL, E-selectins, phosphatidylserine, oxLDL | [206,221,231,232] |
| SR-E1 (LOX-1) | EC, VSMC, Мf, platelets | oxLDL, AGE, CRP, apoptosis products, HSP, activated platelets | [206,221,233,234,235] |
| SR-E3 (CD206, MR-1) | Мf | Microbial glycans, altered plasma glycoproteins, collagen, HSP70 | [236,237,238,239,240] |
| SR-F1 (SREC-I) | EC, Мf |
oxLDL, acLDL, calcium-binding proteins (advillin, calretinulin), PAMP, HSP, C1q | [206,221,235,241,242] |
| SR-F2 (SREC-II) | EC, Мf | acLDL, C1q, calreticulin | [243] |
| SR-G1 (CXCL16) | Мf, VSMC, platelets | oxLDL, PAMP, products of apoptosis and cell necrosis, CXCR6 | [219,221,244,245] |
| SR-H1 (Stabilin-1) | Мf | PAMP, oxLDL, acLDL, heparin, hyaluronate, phosphatidylserine | [246,247,248] |
| SR-H2 (Stabilin-2) | Мf, EC | PAMP, oxLDL, acLDL, acid glycans, nucleic acids, phosphatidylserine | [247,249] |
| SR-I1 (CD163) | Мf, monocytes | Complexes hemoglobin-haptoglobin, fibronectin, PAMP | [250,251,252,253] |
| SR-J1 (RAGE) | Мf, EC, VSMC | AGE, phosphatidylserine, oxLDL, DAMP (S-100, HMGB1), HSP70, Mac-1 (CD11b/CD18) | [221,254,255,256] |
| SR-K1 (CD44) | Leukocytes, Мf | Hyaluronate, collagens, fibronectin, laminin, E-selectins, fibrin, osteopontin, metalloproteinases | [257,258,259] |
| SR-L1 (CD91, LRP1) | VSMC, Mf, monocytes |
Apolipoprotein E, oxLDL, proteinase-antiproteinase complexes, HSP, C1q, integrins, thrombospondins, fibronectin, lactoferrin, PDGF | [260,261,262] |
Note. Cells: Mf—macrophages, EC—endothelial cells, VSMC—vascular smooth muscle cells. Ligands: PAMP—pathogen-associated molecular patterns, HSP—heat shock proteins (from the families: HSP70, HSP90, HSP110), AGE—Advanced Glycation End products, FFA—free fatty acids, C1q—complement system factor, acLDL—acetylated low-density lipoproteins (LDL), oxLDL/acLDL—oxidized/acetylated LDL, HDL—high-density lipoprotein, CXCR6—chemokine receptor, CRP—C-reactive protein, HMGB1—nuclear non-histone protein with DAMP function, S-100—calcium-binding proteins with DAMP function, Mac-1 (CD11b/CD18) — beta-2-integrin, PDGF—platelet-derived growth factor.