Table 5.
Opioid addiction and emerging deregulated ncRNAs.
| ncRNA | Targets | References | |
|---|---|---|---|
| Addictive-like behavior | miRNA592-3p | DRD2 REST |
[148] |
| Heroin craving | miRNA181a | MeCP2 | [147] |
| Heroin seeking | miRNA218 | MeCP2 | [145] |
| Morphine craving | circTmeff-1 |
miRNA541-5p
miRNA6934-3p |
[153] |
| miRNA592-3p | TMFF1 | [153] | |
| Morphine-taking behaviour | miRNA1298-5p | - | [144] |
| miRNA32-5p |
Dusp5
Btg2 Cldn11 Dcaf6 |
[144] | |
| Morphine withdrawal symptoms | miRNA132-3p | - | [142] |
| Reconsolidation of cocaine-associated memory | circTmeff-1 |
miRNA206 BDNF |
[155] |
BDNF: Brain-derived neurotrophic factor; Btg2: BTG anti-proliferation factor 2; Cd69: CD69 molecule; Cldn11: claudin 11; DRD2: dopamine D2 receptor; REST: RE1-silencing transcription factor; Tmeff-1: tomoregulin-1; -: not tested.